Average Volume Assured Pressure Support
Clinical Proof
“Average Volume Assured Pressure Support in Obesity Hypoventilation: a Randomized Cross-Over Trial”
Jan Hendrik Storre, MD; Benjamin Seuthe; René Fiechter, MD; Stavroula Milioglou; Michael Dreher, MD; Stephan Sorichter, MD; and Wolfram Windisch, MD

CHEST, September 2006

This study conducted on 10 patients with obesity hypoventilation syndrome (OHS) showed that BiPAP S/T substantially improves sleep quality and specific aspects of the quality of life, the addition of AVAPS further improves the decrease of PtcCO2

Conference Abstract
Average Volume Assured Pressure Support (AVAPS) for Pressure-Controlled Ventilation (BiPAP® Therapy)
Jens Kerl, Markus Wenzel, Thomas Barchfeld, Dieter Köhler, Fachkrankenhaus Kloster Grafschaft, Schmallenberg

This paper deals with 3 clinical cases, patients with chest deformities, in whom the application of conventional ventilation methods (2 Pressure-Controlled Ventilation and 1 Volume-Controlled Ventilation) did not produce satisfactory results.
After switching to AVAPS, results included an increase in average SpO2, reduction of pCO2 and an improved acceptance of therapy compared to previously used ventilation methods.

AVAPS technology makes it possible to combine the comfort and leak compensation of a pressure mode, and the safety and efficiency of an adaptable pressure support to fit current physiological conditions.

Short-Term Efficacy of Spontaneous AVAPS (Average Volume Assured Pressure Support) Mask Ventilation in Patients with Hypercapnic COPD
A.Tramacere, M.Romagnoli, T.Bellantone, R.Lubello, D.Lugli, L.Trianni, E.Clini Fondazione Villa Pineta and University of Modena-Reggio Emilia. Pneumology and Pulmonary Rehabilitation Dpt. Pavullo (MO), Italy.

The aim of this study was to evaluate the short-term clinical efficacy of spontaneous mask AVAPS versus PS ventilation in patients with hypercapnic chronic respiratory insufficiency. The primary end-point was to assess changes in blood gases whereas the secondary endpoint was to record the patient’s comfort under these two different modalities.

Results, including 10 stable COPD patients, are summarized in the following table:

PaCO2 and patient comfort (VAS) have been significantly improved at the end of supported breathing.
Short-term AVAPS mask ventilation is feasible and effective in stable COPD patients with hypercapnia.

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